Eunicellin-Based Diterpenoids, Hirsutalins N–R, from the Formosan Soft Coral Cladiella hirsuta
Tzu-Zin Huang 1,†email, Bo-Wei Chen 1,†email, Chiung-Yao Huang 1email, Tsong-Long Hwang 2email, Chang-Feng Dai 3email and Jyh-Horng Sheu 1,4,5,6,7,*

Abstract: New eunicellin-type hirsutalins N–R (1–5), along with two known eunicellins, (6 and 7) were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxic activity of compounds 1–7 against the proliferation of a limited panel of cancer cell lines was measured. The in vitro anti-inflammatory activity of compounds 1–7 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils.

Keywords: soft coral; Cladiella hirsuta; eunicellins: cytotoxic activity; anti-inflammatory activity